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Anästhesiol Intensivmed Notfallmed Schmerzther 2010; 45(3):170-173 DOI: 10.1055/s-0030-1249398

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Publication Date:15 March 2010 (online)

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Gemäß der bislang verfügbaren Evidenz ist die mitunter zu beobachtende Induktion von Husten nach Applikation von Opioiden in letzter Konsequenz nicht geklärt. Die bekannten Opioidwirkungen lassen vielfältige Erklärungsmodelle zu, weswegen es in der Folge einer Opioidapplikation zum Hustenreiz kommt. Diese sind hier skizziert worden. Obgleich auch in Hinblick auf die Interventionen eine sehr heterogene Datenlage vorherrscht, weist die gegebene Literaturzusammenstellung doch auf klinisch praktikable Möglichkeiten hin, wie ein Hustenreiz nach Opiatgabe gemäß der besten zur Verfügung stehenden Evidenz zu vermeiden ist. Beispielhaft sind in diesem Zusammenhang nach gegenwärtigem Kenntnisstand die langsame Opioidgabe und die Vorgabe von Substanzen (z.B. Lidocain, Clonidin) zu nennen.

The (intravenous) administration of opioids is frequently associated with the induction of cough. This phenomenon is usually neither harmful for the patient nor bothersome. However, in some situations a severe cough may interfere with imaging, diagnostic or therapeutic procedures and thus, anesthesiologists may want to know effective preventive measures. The existing literature is extremely diverse and the results of clinical trials are sometimes conflicting. Based on experimental investigations in accordance with clinical findings this systematic review of the existing evidence helps to guide the management strategy if opioid induced cough should be avoided. Promising strategies – among others – in order to achieve this aim consist for instance of decreasing the injection speed in conjunction with pre-administration of lidocaine or clonidine.

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Andrew Martonik

Best overall: Samsung Galaxy S9+

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The Galaxy S9+ isn't much different from its predecessor, but seeing as it was Samsung's best-ever-selling phone, that's not a bad thing. The S9+ is all about giving you the most features in the most beautiful package. You get top-end specs across the board, plus all of the hardware features you expect: waterproofing, wireless charging, an SD card slot, a headphone jack and more.

The camera is all-new this year, with a sensor that does fantastic processing to remove noise and sharpen fine detail. It's aided by a dual-aperture lens to get the best combination of light and detail in different shots, and is paired with a secondary telephoto lens for zoom and portrait mode shooting.

You don't get the clean and simple software experience of the Pixel 2 XL, which may take some extra customization and tweaking on your part, but the Galaxy S9+ is far less polarizing overall — just about anyone looking for a high-end phone will love using it.

Bottom line: The Galaxy S9+ doesn't require much thought — it can do everything, and looks great doing it, with few real downsides.

One more thing: If you're looking for a smaller version of the S9+, the S9 has a smaller battery and only one camera sensor but is otherwise the same phone. Which means it's just as good.

Why the Samsung Galaxy S9+ is the best Android phone

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builds on years of Samsung's excellence making some of the most popular and best-selling phones around the world. It starts with a gorgeously sculpted metal and glass body, available in three colors, that's waterproof but still includes great features like dual speakers, a headphone jack and an SD card slot. Inside are the latest and greatest specs, plus a standout pair of cameras on the back and the best display on the market around front.

Samsung designs its phones to be appealing to the widest possible audience, and that makes the Galaxy S9+ a great device for just about anyone. It has a big and beautiful display that's quite simply the best in the industry, but with very small bezels and curved edges it fits into a relatively compact size.

Internally, it has all of the latest specs to handle any app or task you need. It also has a pair of cameras on the back that are in the mix as the best available today. Samsung has also kept around crowd-pleasing features like wireless charging, waterproofing, an SD card slot and a headphone jack. Really, the Galaxy S9+ does a great job at being all things to all people.

Best of all, if you don't care for the larger size of the Galaxy S9+ for whatever reason, you can simply buy the smaller and less expensive Galaxy S9 instead and get the same core experience with only a few changes.

Is it a good time to buy?

The Samsung Galaxy S9+ launched the first week of March 2018, meaning it is still the latest and great phone that Samsung makes. The Galaxy Note 9 is expected to launch around October 2018, which will likely be only a marginal improvement over the Galaxy S9+, and the Galaxy S9+'s successor will not be unveiled until March 2019.

8 reasons to buy

3 reasons not to buy

Samsung designs its phones to be appealing to the widest possible audience.

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